Layout is a powerful tool to create intrigue and guide the eye over time. There aren’t hard-and-fast rules here; every composition is an experiment. Here are examples of some pretty successful ones:
This poster by Josef Müller-Brockmann (the best poster designer of all time) is a lovely example of how to create focus, then lead the reader on a journey.
Here’s an outdated version of my resume. See how I used layered rectangles to lead the eye?